The Pinney Group

Peer Reviewed Publications

Synthesis of Structurally Diverse Benzosuberene Analogues and their Biological Evaluation as Anti-cancer Agents
Tanpure, R. P.; George, C. S.; Strecker, T. E.; Devkota, L.; Tidmore, J. K.; Lin, C.-M.; Herdman, C. A.; MacDonough, M. T.; Sriram, M.; Chaplin, D. J.; Trawick, M. L.; Pinney, K. G. Bioorganic and Medicinal Chemistry, Manuscript accepted for publication on August 18, 2013.

Synthesis of 2-Aryl-3-Aroyl-Indole Salt (OXi8007) Resembling Combretastatin A-4 with Application as a Vascular Disrupting Agent
Hadimani, M. B.; MacDonough, M. T.; Ghatak, A.; Strecker, T. E.; Lopez, R.; Sriram, M.; Nguyen, B. L.; Hall, J. J.; Kessler, R. J.; Shirali, A. R.; Liu, L.; Garner, C. M.; Pettit, G. R.; Hamel, E.; Chaplin, D. J.; Mason, R. P.; Trawick, M. L.; Pinney, K. G. Journal of Natural Products, Manuscript accepted for publication on July 31, 2013.

Synthesis and Biological Evaluation of Indole-based, Anti-cancer Agents Inspired by the Vascular Disrupting Agent 2-(3'-hydroxy-4'-methoxyphenyl)-3-(3",4",5"-trimethoxybenzoyl)-6-methoxyindole (OXi8006)
MacDonough, M. T.; Strecker, T. E.; Hamel, E.; Hall, J. J.; Chaplin, D. J.; Trawick, M. L.; Pinney, K. G. Bioorganic and Medicinal Chemistry, Manuscript accepted for publication on July 11, 2013.

Small-Molecule Inhibitors of Cathepsin L Incorporating Functionalized Ring-Fused Molecular Frameworks
Song, J.; Jones, L. M.; Chavarria, G. E.; Charlton-Sevcik, A. K.; Jantz, A.; Johansen, A.; Bayeh, L.; Soeung, V.; Snyder, L. K.; Lade, Jr., S. D.; Chaplin, D. J.; Trawick, M. L.; Pinney, K. G. Bioorganic Medicinal Chemistry Letters, 23: 2801-2807, 2013.

Initial Evaluation of the Antitumour Activity of KGP94, a Functionalized Benzophenone Thiosemicarbazone Inhibitor of Cathepsin L
Chavarria, G. E.; Horsman, M. R.; Arispe, W. M.; Kumar, G. D. K.; Chen, S.-E.; Strecker, T. E.; Parker, E. N.; Chaplin, D. J.; Pinney, K. G.; Trawick, M. L. European Journal of Medicinal Chemistry, 58: 568-572, 2012.

Synthesis and Biochemical Evaluation of Thiochromanone Thiosemicarbazone Analogues as Inhibitors of Cathepsin L
Song, J.; Jones, L. M.; Kumar, G. D. K.; Conner, E. S.; Bayeh, L.; Chavarria, G. E.; Charlton-Sevcik, A. K.; Chen, S.-E.; Chaplin, D. J.; Trawick, M. L.; Pinney, K. G. ACS Medicinal Chemistry Letters, 3: 450-453, 2012.

An Amino-Benzosuberene Analogue That Inhibits Tubulin Assembly and Demonstrates Remarkable Cytotoxicity
*Tanpure, R. P.; *George, C. S.; *Sriram, M.; Strecker, T. E.; Tidmore, J. K.; Hamel, E.; Charlton-Sevcik, A. K.; Chaplin, D. J.; Trawick, M. L.; Pinney, K. G. MedChemComm, 3: 720-724, 2012.
[* denotes authors with equal contributions]

Regioselective Synthesis of Water Soluble Monophosphate Derivatives of Combretastatin A-1
Tanpure, R. P.; Nguyen, B. L.; Strecker, T. E.; Aguirre, S.; Sharma, S.; Chaplin, D. J.; Siim, B. G.; Hamel, E.; Lippert, J. W. III; Pettit, G. R.; Trawick, M. L.; Pinney, K. G. Journal of Natural Products 74: 1568-1574, 2011.

A Perspective on Vascular Disrupting Agents that Interact with Tubulin: Preclinical Tumor Imaging and Biological Assessment
Mason, R. P.; Zhao, D.; Liu, L.; Trawick, M. L.; Pinney, K. G. Integr. Biol. 3: 375-387, 2011.
(Invited contribution to honor Professor Mina J. Bissell for her lifetime contributions to the tumor microenvironment and research involving the extracellular matrix)

Functionalized Benzophenone, Thiophene, Pyridine, and Fluorene Thiosemicarbazone Derivatives as Inhibitors of Cathepsin L
Kumar, G. D. K.; Chavarria, G. E.; Charlton-Sevcik, A. K.; Yoo, G. K.; Song, J.; Strecker, T. E.; Siim, B. G.; Chaplin, D. J.; Trawick, M. L.; Pinney, K. G. Bioorg. Med. Chem. Lett. 20: 6610-6615, 2010.

Regio- and Stereospecific Synthesis of Mono -D-Glucuronic Acid Derivatives of Combretastatin A-1
Tanpure, R. P.; Strecker, T. E.; Chaplin, D. J.; Siim, B. G.; Trawick, M. L.; Pinney, K. G. J. Nat. Prod. 73: 1093-1101, 2010.

Design, synthesis, and biological evaluation of potent thiosemicarbazone based cathepsin L inhibitors
Kumar, G. D. K.; Chavarria, G. E.; Charlton-Sevcik, A. K.; Arispe, W. M.; MacDonough, M. T.; Strecker, T. E.; Chen, S.-E.; Siim, B. G.; Chaplin, D. J.; Trawick, M. L.; Pinney, K. G. Bioorg. Med. Chem. Lett. 20: 1415-1419, 2010.

Application of the McMurry Coupling Reaction in the Synthesis of Tri- and Tetra-arylethylene Analogues as Potential Cancer Chemotherapeutic Agents
Tanpure, R. P.; Harkrider, A. R.; Strecker, T. E.; Hamel, E.; Trawick, M. L.; Pinney, K. G. Bioorg. Med. Chem. 17: 6993-7001, 2009.

Carbon-14 Radiosynthesis of Combretastatin A-1 (CA1) and its Corresponding Phosphate Prodrug (CA1P)
Brown, R. T.; Murrell, V. L.; McMordie, A.; Sriram, M.; Pinney, K. G.; Sharma, S.; Chaplin, D. J. J. Labelled Compd. Rad., 52: 567-570, 2009.

Development of Synthetic Methodology Suitable for the Radiosynthesis of Combretastatin A-1 (CA1) and its Corresponding Prodrug CA1P
Shirali, A.; Sriram, M.; Hall, J. J.; Nguyen, B. L.; Guddneppanavar, R.; Hadimani, M. B.; Ackley, J. F.; Siles, R.; Jelinek, C. J.; Arthasery, P.; Brown, R. C.; Murrell, V. L.; McMordie, A.; Sharma, S.; Chaplin, D. J.; Pinney, K. G. J. Nat. Prod. 72: 414-421, 2009.

Design, Synthesis and Biological Evaluation of Dihydronaphthalene and Benzosuberene Analogs of the Combretastatins as Inhibitors of Tubulin Polymerization in Cancer Chemotherapy
Sriram, M.; Hall, J. J.; Grohmann, N. C.; Strecker, T. E.; Wootton, T.; Franken, A.; Trawick, M. L.; Pinney, K. G. Bioorg. Med. Chem. 16: 8161-8171, 2008.

Design, Synthesis, Biochemical, and Biological Evaluation of Nitrogen-Containing Triflouro Structural Modifications of Combretastatin A-4
Hall, J. J.; Sriram, M.; Strecker, T. E.; Tidmore, J. K.; Jelinek, C. J.; Kumar, G. D. K.; Hadimani, M. B.; Pettit, G. R.; Chaplin, D. J.; Trawick, M. L.; Pinney, K. G. Bioorg. Med. Chem. Lett. 18: 5146-5149, 2008.

Combretastatin Dinitrogen-Substituted Stilbene Analogues as Tubulin-Binding and Vascular-Disrupting Agents
Siles, R.; Ackley, J. F.; Hadimani, M. B.; Hall, J. J.; Mugabe, B. E.; Guddneppanavar, R.; Monk, K. A.; Chapuis, J.-C.; Pettit, G. R.; Chaplin, D. J.; Edvardsen, K.; Trawick, M. L.; Garner, C. M.; Pinney, K. G. J. Nat. Prod. 71: 313-320, 2008.

Design, Synthesis and Biochemical Evaluation of Novel Cruzain Inhibitors with Potential Application in the Treatment of Chagas' Disease
Siles, R.; Chen, S.-E.; Zhou, M.; Pinney, K. G.; Trawick, M. L. Bioorg. Med. Chem. Lett. 16: 4405-4409, 2006.

Synthesis and Characterization of 2,6-Bis-Hydrazinopyridine, and its Conversion to 2,6-Bis-Pyrazolypyridines
Brien, K. A.; Garner, C. M.; Pinney, K. G. Tetrahedron 62: 3663-3666, 2006.

Design, Synthesis, and Biological Evaluation of Combretastatin Nitrogen-Containing Derivatives as Inhibitors of Tubulin Assembly and Vascular Disrupting Agents
Monk, K. A.; Siles, R.; Hadimani, M. B.; Mugabe, B. E.; Ackley, J. F.; Studerus, S. W.; Edvardsen, K.; Trawick, M. L.; Garner, C. M.; Rhodes, M. R.; Pettit, G. R.; Pinney, K. G. Bioorg. Med. Chem. 14: 3231-3244, 2006.

Synthesis and Crystal Structures of Two Novel 3,4,5-Trimethoxyphenyl Derivatives from (Z)-1-[(2',3'-Dinitro-4'-Methoxy)-Phenyl]-2-[(3'',4'',5''-trimethoxy)-phenyl] Ethene
Miranda, M. G.; Norton, E. J.; Feazell, R. P.; Klausmeyer, K. K.; Pinney, K. G. J. Chem. Crystallogr. 36: 309-314, 2006.

Combretastatin A-4 Resistance in H460
Human Lung Carcinoma Demonstrates Distinctive Alterations in β-Tubulin Isotope Expression

Wehbe, H.; Kearney, C. M.; Pinney, K. G. Anticancer Res. 25: 3865-3870, 2005.

Combretastatin Family Member Oxi4503 Induces Tumor Vascular Collapse Through the Induction of Endothelial Apoptosis
Sheng, Y.; Hua, J.; Pinney, K. G.; Garner, C. M.; Kane, R. R.; Prezioso, J. A.; Chaplin, D. J.; Edvardsen, K. Int. J. Cancer 111: 604-610, 2004.

Synthesis and Biological Evaluation of 2-(4-Flourophenoxy)-2-Phenyl-Ethyl Piperazines as Seratonin-Selective Reuptake Inhibitors with a Potentially Improved Adverse Reaction Profile
Dorsey, J. M.; Miranda, M. G.; Cozzi, N. V.; Pinney, K. G. Bioorg. Med. Chem. 12: 1483-1491, 2004.

Synthesis of 4-Methoxy-3,5-Dinitrobenzaldehyde: A Correction to Supposed tele Nucleophilic Aromatic Substitution
Monk, K. A.; Siles, R.; Pinney, K. G.; Garner, C. M. Tetrahedron Lett. 44: 3759-3761, 2003.

Oxi4503, a Novel Vascular Targeting Agent: Effects on Blood Flow and Antitumor Activity in Comparison to Combretastatin A-4 Phosphate
Hua, J.; Sheng, Y.; Pinney, K. G.; Garner, C. M.; Kane, R. R.; Prezioso, J. A.; Pettit, G. R.; Chaplin, D. J.; Edvardsen, K. Anticancer Res. 23: 1433-1440, 2003.

Synthesis, In Vitro, and In Vivo Evaluation of Phosphate Ester Derivatives of Combretastatin A-4
Hadimani, M. B.; Hua, J.; Jonklaas, M. D.; Kessler, R. J.; Sheng, Y.; Olivares, A.; Tanpure, R. P.; Weiser, A.; Zhang, J.; Edvardsen, K.; Kane, R. R.; Pinney, K. G. Bioorg. Med. Chem. Lett. 13: 1505-1508, 2003.

Synthesis of Methoxy and Hydroxy Containing Tetralones: Versatile Intermediates for the Preparation of Biologically Relevent Molecules
Ghatak, A.; Dorsey, J. M.; Garner, C. M.; Pinney, K. G. Tetrahedron Lett. 44: 4145-4148, 2003.

2-(3-tert-Butyldimethylsiloxy-4-methoxyphenyl)-6-methoxy-3-(3,4,5-Trimethoxybenzoyl)indole
Hadimani, M. B.; Kessler, R. J.; Kautz, J. A.; Ghatak, A.; Shirali, A. R.; O'Dell, H.; Garner, C. M.; Pinney, K. G. Acta Cryst. C58: o330-o332, 2002.

Preparation of New Anti-tubulin Ligands through a Dual-Mode, Addition-Elimination Reaction to a Bromo-Substituted a,β-Unsaturated Sulfoxide
Chen, Z.; Mocharla, V. P.; Farmer, J. M.; Pettit, G. R.; Hamel, E.; Pinney, K. G. J. Org. Chem. 65: 8811-8815, 2000.

Synthesis and Biological Evaluation of Aryl Azide Derivatives of Combretastatin A-4 as Molecular Probes for Tubulin
Pinney, K. G.; Mejia, M. P.; Villalobos, V. M.; Rosenquist, B. E.; Pettit, G. R.; Verdier-Pinard, P.; Hamel, E. Bioorg. Med. Chem. 8: 2417-2425, 2000.

A New Anti-tubulin Agent Containing the Benzo[b]Thiophene Ring System
Pinney, K. G.; Bounds, A. D.; Dingeman, K. M.; Mocharla, V. P.; Pettit, G. R.; Bai, R.; Hamel, E. Bioorg. Med. Chem. Lett. 9: 1081-1086, 1999.

(E)-1-(3-Methoxy-4-Nitrophenyl)-2-(3,4,5-Trimethoxyphenyl)Ethane
Mullica, D. F.; Pinney, K. G.; Mejia, P.; Rosenquist, B. E.; Sappenfield, E. L. Acta Cryst. C54: 695-697, 1998.

Characterization and Structural Analyses of Trimethoxy and Triethoxybenzo[b]Thiophene
Mullica, D. F.; Pinney, K. G.; Mocharla, V. P.; Dingeman, K. M.; Bounds, A. D.; Sappenfield, E. L. J. Chem. Crystallogr. 28: 289-295, 1998.

X-ray Structures of Two Methoxybenzo[b]thiophenes
Mullica, D. F.; Pinney, K. G.; Dingeman, K. M.; Bounds, A. D.; Sappenfield, E. L. J. Chem. Crystallogr. 26: 801-806, 1996.

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Book Chapters

Pinney, K. G.; Pettit, G. R.; Trawick, M. L.; Jelinek, C.; Chaplin, D. J. The Discovery and Development of the Combretastatins. In Antitumor Agents from Natural Products, 2nd Edition, D. Kingston, D. Newman, and G. Cragg, eds. Boca Raton, FL: CRC Press, Taylor and Francis Group, published October 3, 2011.

Pettit, G. R.; Pinney, K. G. "The Combretastatins" included in the Chapter entitled: Major Milestones. In American Society of Pharmacognosy History, G. Cragg, ed., Anticipated availability 2009.

Pinney, K. G. Molecular Recognition of the Colchicine Binding Site as a Design Paradigm for the Discovery and Development of Vascular Disrupting Agents. In Vascular-targeted Therapies in Oncology, D. W. Siemann, ed., 95-121. London, UK: John Wiley & Sons, 2006.

Pinney, K. G.; Jelinek, C.; Edvardsen, K.; Chaplin, D. J.; Pettit, G. R. The Discovery and Development of the Combretastatins. In Antitumor Agents from Natural Products, D. Kingston, D. Newman, and G. Cragg, ed., 23-46. Boca Raton, FL: CRC Press, 2005.

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Patents

Combretastatin Analogs with Tubulin Binding Activity
Kevin G. Pinney, Madhavi Sriram. United States Patent (US 8,394,859), issued March 12, 2013.

Compositions and Methods with Enhanced Therapeutic Activity
David J. Chaplin, Klaus Edvardsen, Kevin G. Pinney, Joseph Prezioso, Mark Wood. United States Patent (US 8,198,302), issued June 12, 2012.

Indole-Containing and Combretastatin-Related Anti-Mitotic and Anti-Tubulin Polymerization Agents
Kevin G. Pinney, Feng Wang, Maria Del Pilar Mejia. European Patent (EP 1 214 298 B1), issued May 30, 2012.

Inhibitors of Cysteine Proteases and Methods of Use Thereof.
Rogelio Siles, Ming Zhou, Freeland J. Ackley, Kevin G. Pinney, Shen-En Chen, Wara Milenka Arispe-Angulo, Mary Lynn Trawick. United States Patent (US 8,173,696), issued May 8, 2012.

Serotonin Reuptake Inhibitors.
Kevin G. Pinney, Maria Graciela Miranda, James Michael Dorsey. United States Patent (US 7,893,261 B2), issued February 22, 2011.

Chromene-derivatives with anti-tubulin and vascular targeting activity
Kevin G. Pinney, Phyllis Arthasery, Anupama Shirali, Klaus Edvardsen, David J. Chaplin. European Patent (EP 1 751 128 B1), issued July 21, 2010.

Chromene-containing compounds with anti-tubulin and vascular targeting activity.
Kevin G. Pinney, Phyllis Arthasery, Anupama Shirali, Klaus Edvardsen, David J. Chaplin. United States Patent (US 7,456,214), issued November 25, 2008.

Combretastatin Analogs with Tubulin Binding Activity.
Kevin G. Pinney, Madhavi Sriram. United States Patent (US 7,429,681 B2), issued September 30, 2008.

Functionalized Stilbene Derivatives as Improved Vascular Targeting Agents.
Chaplin, David J.; Garner III, Charles Manly; Kane, Robert; Pinney, Kevin G.; Prezioso, Joseph Anthony; Edvardsen, Klaus. United States Patent (US 7,384,925), issued June 10, 2008.

Tubulin Binding Agents and Corresponding Prodrug Constructs.
Kevin G. Pinney, Vani P. Mocharla, Zhi Chen, Charles M. Garner, Mallinath Hadimani, Raymond Kessler, James M. Dorsey, Klaus Edvardsen, David J. Chaplin, Joseph Prezioso, Anjan Ghatak (Usha R. Ghatak). United States Patent (US 7,091,240), issued August 15, 2006.

Tubulin Binding Agents and Corresponding Prodrug Constructs.
Kevin G. Pinney, Vani P. Mocharla, Zhi Chen, Anjan Ghatak (Usha R. Ghatak), Mallinath Hadimani, Jimmy Kessler, James M. Dorsey, Klaus Edvardsen, David J. Chaplin, Joseph Prezioso. United States Patent (US 7,001,926 B2), issued February 21, 2006.

Compositions and Methods for Use in Targeting Vascular Destruction.
Ronald W. Pero, David Sherris, Kevin G. Pinney, Vani P. Mocharla, Zhi Chen. U.S. Patent Application (Serial No. 10/218,833), filed August 14, 2002. United States Patent (US 6,956,054), issued October 18, 2005.

Functionalized Stilbene Derivatives as Improved Vascular Targeting Agents.
David J. Chaplin, Charles Manly Garner III, Robert Ronald Kane, Kevin G. Pinney, Joseph Anthony Prezioso, and Klaus Edvardsen. United States Patent (US 6,919,324 B2), issued July 19, 2005.

Indole-Containing and Combretastatin-Related Anti-Mitotic and Anti-Tubulin Polymerization Agents.
Kevin G. Pinney, Feng Wang, and Mallinath Hadimani. Australian Patent Application (No. 2000074934), filed September 15, 2000. Australian Patent, issued February 17, 2005.

Indole-Containing and Combretastatin-Related Anti-Mitotic and Anti-Tubulin Polymerization Agents.
Kevin G. Pinney, Feng Wang, and Mallinath Hadimani. United States Patent (US 6,849,656 B1), issued February 1, 2005.

Anti-Mitotic Agents Which Inhibit Tubulin Polymerization.
Kevin G. Pinney, Maria del Pilar Mejia, Vani P. Mocharla, Anupama Shirali, George R. Pettit. Australian Patent Application (No. 765418), issued January 15, 2004.

Tubulin Binding Ligands and Corresponding Prodrug Constructs.
Kevin G. Pinney, Vani P. Mocharla, Zhi Chen, Charles M. Garner, Anjan Ghatak, Jimmy Dorsey. U.S. Patent Application, filed on March 12, 2001. United States Patent (US 6,593,374), issued July 15, 2003.

Tubulin Binding Ligands and Corresponding Prodrug Constructs.
Kevin G. Pinney, Vani P. Mocharla, Zhi Chen, Charles M. Garner, Anjan Ghatak, Mallinath Hadimani, Jimmy Kessler, and Jimmy Dorsey. U.S. Patent Application, filed on March 12, 2001. United States Patent (US 6,593,374), issued July 15, 2003.

Anti-Mitotic Agents Which Inhibit Tubulin Polymerization.
Kevin G. Pinney, Maria del Pilar Mejia, Vani P. Mocharla, Anupama Shirali, George R. Pettit. U.S. Patent (Serial No. US 6,350,777) based on PCT/US98/04380, issued February 26, 2002.

Anti-Mitotic Agents Which Inhibit Tubulin Polymerization.
Kevin G. Pinney, Maria del Pilar Mejia, Vani P. Mocharla, Anupama Shirali, George R. Pettit. Australian Patent Application (No. 732917) based on PCT/US98/04380, issued August 16, 2001.

Anti-Mitotic Agents Which Inhibit Tubulin Polymerization.
Kevin G. Pinney, Pilar Mejia, Vani P. Mocharla, Anupama Shirali, George R. Pettit. U.S. Patent Application (Serial No. 06,162,930), based on PCT/US98/04380, issued December 19, 2000.

Anti-Mitotic Agents Which Inhibit Tubulin Polymerization.
Kevin G. Pinney, Baylor University, Application for United States Letters Patent, filed March 6, 1997. United States Patent (US 5,886,025), issued, March 23, 1999.

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Publications prior to Baylor University

Stereoselective Synthesis of 2,5-Dihydrofurans by Sequential SN2 Cleavage of Alkynyloxiranes and Ag+-Catalyzed Cyclization of the Allenylcarbinol Products
Marshall, J. A.; Pinney, K. G. J. Org. Chem. 58: 7180-7184, 1993.

Structural and Computational Modeling Studies on 3-Aroyl-2-arylbenzo[b]thiophene Estrogen Receptor Ligands: LY117018 and Aryl Azide Photoaffinity Labeling Analogs; Investigation of Conformational Preferences, Differential Photoreactivity, and Preferential Modes of Binding
Kym, P.R.; Anstead, G. M.; Pinney, K. G.; Wilson, S. R.; Katzenellenbogen, J. A. J. Med. Chem. 36: 3910-3922, 1993.

Non-Steroidal Estrogens Bearing Acyl Azide Functions: Potential Electrophilic and Photoaffinity Labeling Agents for the Estrogen Receptor
Pinney, K. G.; Carlson, K. E.; Katzenellenbogen, J. A. Steroids 57: 222-232, 1992.

Synthesis of a Tetrafluoro-Substituted Aryl Azide and Its Protio Analogue as Photoaffinity Labeling Reagents for the Estrogen Receptor
Pinney, K. G.; Katzenellenbogen, J. A. J. Org. Chem. 56: 3125-3133, 1991.

Efficient and Selective Photoaffinity Labeling of the Estrogen Receptor Using Two Nonsteroidal Ligands That Embody Aryl Azide or Tetrafluoroaryl Azide Photoreactive Functions
Pinney, K. G.; Carlson, K. E.; Katzenellenbogen, B. S.; Katzenellenbogen, J. A. Biochemistry 30: 2421-2431, 1991.

Torsionally and Hydrophobically Modified 2,3-Diarylindenes as Estrogen Receptor Ligands
Anstead, G. M.; Peterson, C. S.; Pinney, K. G.; Wilson, S. R.; Katzenellenbogen, J. A. J. Med. Chem. 33: 2726-2734, 1990.

Target Tissue Uptake Selectivity of Three Fluorine-Substituted Progestins: Potential Imaging Agents for Receptor-Positive Breast Tumors
Pomper, M. G.; Pinney, K. G.; Carlson, K. E.; Mathias, C. J.; Welch, M. J.; Katzenellenbogen, J. A. Nucl. Med. Biol. (Int. J. Radiat. Appl. Instrum., Part B) 17: 309-319, 1990.

[3H]DU41165: A High Affinity Ligand and Novel Photoaffinity Labeling Reagent for the Progesterone Receptor
Pinney, K. G.; Carlson, K. E.; Katzenellenbogen, J. A. J. Steroid Biochem. 35(2): 179-189, 1990.

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